Sphingosine-1-Phosphate (S1P) Stimulation Decreases Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) Secretion in Follicular Thyroid Cancer Cell Lines in Vitro Authors: A. C. Grover and P. J. Yannie Departments: Surgery
نویسنده
چکیده
Background: An estimated 37,340 new cases of thyroid cancer will be diagnosed in 2008. As high as Women will count for 75% of these new cases and over 50% of deaths from thyroid cancer. Although thyroid cancer has an excellent prognosis, an important subset is difficult to treat and radioresistant. Angiogenesis is critical for tumor growth. VEGF and IL8 are proangiogenic factors. S1P is a bioactive lipid involved in angiogenesis and an emerging target for cancer therapies.
منابع مشابه
Title : Sphingosine - 1 - Phosphate ( S 1 P ) Stimulation Decreases Vascular Endothelial Growth Factor ( VEGF ) and Interleukin - 8 ( IL - 8 ) Secretion in Follicular Thyroid Cancer
Background: An estimated 37,340 new cases of thyroid cancer will be diagnosed in 2008. As high as Women will count for 75% of these new cases and over 50% of deaths from thyroid cancer. Although thyroid cancer has an excellent prognosis, an important subset is difficult to treat and radioresistant. Angiogenesis is critical for tumor growth. VEGF and IL8 are proangiogenic factors. S1P is a bioac...
متن کاملInteractions between sphingosine-1-phosphate and vascular endothelial growth factor signalling in ML-1 follicular thyroid carcinoma cells.
Sphingosine-1-phosphate (S1P) induces migration of human ML-1 thyroid follicular cancer cells and inhibits migration of human FRO anaplastic thyroid cancer cells. As tumour cells often secrete vascular endothelial growth factor (VEGF), we investigated a possible interaction between S1P and VEGF signalling in the regulation of thyroid tumour cell migration. We found that both ML-1 and FRO cells ...
متن کاملQuantitation of Vascular Endothelial Growth Factor and Interleukin-6 in Different Stages of Breast Cancer
Background: Determination of the impact of angiogenesis on tumor development and progression is essential. This study aimed to determine the serum levels of Vascular endothelial growth factor (VEGF) and Interleukin 6 (IL-6) in breast carcinoma, and to correlate them with tumor size, lymph node involvement, and cancer stage. Methods: Under aseptic precautions 5 ml of venous blood was collecte...
متن کاملSphingosine 1-Phosphate and Cancer: Lessons from Thyroid Cancer Cells
Sphingomyelin is found in the cell membrane of all eukaryotic cells, and was for a long time considered merely as a structural component. However, during the last two decades, metabolites of sphingomyelin, especially sphingosine 1-phosphate (S1P), have proven to be physiologically significant regulators of cell function. Through its five different G protein-coupled receptors, S1P regulates a wi...
متن کاملSphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2
Mast cells (MC) are present in most vascularized tissues around the vasculature likely exerting immunomodulatory functions. Endowed with diverse mediators, resident MC represent first-line fine-tuners of local microenvironment. Sphingosine-1-phosphate (S1P) functions as a pluripotent signaling sphingolipid metabolite in health and disease. S1P formation occurs at low levels in resting MC and is...
متن کامل